Acne Vulgaris Treatment Linked to Sore Throats Acne Vulgaris: Acne Vulgaris Treatment Linked to Sore Throats

Acne Vulgaris Treatment Linked to Sore Throats

Given oral antibiotics for acne vulgaris can have a sore throat, the researchers say, although why this happens is unclear.

After adjustment, pharyngitis was 4.34 times more likely among students to take oral antibiotics for acne than among those not taking medication (95% CI 1.51 to 12.47), David J. Margolis, MD, PhD, University of Pennsylvania in Philadelphia, and colleagues.

The results of a prospective longitudinal study appearing online in the Archives of Dermatology.

"While the causes of this phenomenon is unknown and should be considered related to the risks versus the benefits of long-term use of oral antibiotics in patients with acne is not caused by group A streptococci," the group wrote.

Previous research has also linked the retrospective and cross-registered for acne oral antibiotics for sore throat, and researchers have suspected that it's because antibiotics kill the beneficial bacteria that inhibit the growth of bad bugs.

For example, one study showed that people who take oral antibiotics for acne have a higher prevalence of colonization by group A streptococcus, which accounted for 90% of bacterial pharyngitis.

But less than 1% of the students examined prospectively in the study by Margolis' colonized by group A streptococci, and colonization did not correlate with pharyngitis.

They note that most of the upper respiratory tract infections and 90% of sore throats are not caused by bacteria at all, probably because the virus instead.

Margolis and colleagues conducted the first study of cross-sectional survey of students at the University of Pennsylvania who has acne. Rates of sore throat in the first 30 days are:

    66.7% among students who reported taking oral antibiotics for acne (10 of 15)
    36.2% of people with acne do not take oral antibiotics (47 of 130)
    28.9% among those who do not have acne and do not take oral antibiotics (35 of 121)

Taking oral antibiotics for acne is associated with an excess of 3.53 times the adjusted self-reported pharyngitis (95% CI 1.14 to 10.95) and odds ratio 4.93 after adjustment for other factors (95% CI 1.41 - 17.23).

The researchers then tested the more stringent link 579 students (61% with acne vulgaris), which was followed prospectively during the school year, with about half of the students assessed in all three points from the beginning to the end of the second half of spring semester.

Among them, 36 students (6.2%) took oral antibiotics for acne during the study. More than 96 (16.6%) had a topical antibiotic for acne.

Pharyngitis level for students to see a health professional was 11.3% among those who received oral antibiotics compared to 3.3% for those without oral antibiotics, a significant difference of 4.34 times the odds of regression analysis of mixtures of logistic models, translating into estimated relative risk 3.91.

Topical antibiotics for acne seems to have no impact on the neck (odds ratio 0.63, 95% CI 0.22 to 1.81).

Hypothesis on oral antibiotics for acne changing microbiota found no support anywhere in this study.

In cross-sectional cohort, only three students - 1.1% - were found colonized with group A streptococcus. All three have acne vulgaris, but none of them take oral antibiotics for him.

In the longitudinal cohort, only eight students colonized with bacteria (0.6%).

Also accounted for the beneficial bacteria cultures of S. salivarius, which naturally inhibits the growth of group A streptococcus bacteria and considered to be sensitive to the antibiotic tetracycline, in contrast with group A streptococcus.

The ability of S. salivarius cultivated to produce a toxin that he used to combat non-group A streptococcal pharyngitis were significantly correlated with students.

But the study does not rule out antibiotics cause overgrowth of more virulent organisms as a mechanism for neck pain with anti-acne antibiotics, the researchers warn.

"When we were swabbing with pharyngitis beginning may not be enough to reflect the completion status for a period of pharyngitis," they wrote.

Another possibility is that the student mistaken for pharyngitis esophagitis, which has been associated with tetracycline.

But the level of pharyngitis was found to be too high for serious diseases, Margolis said the group, called pill-induced esophagitis is not possible explanation.

Another limitation is the limited amount of assessment in the longitudinal analysis, a high school dropout rate, self-report cross-sectional analysis, and the possibility of residual confounding factors such as smoking.

source: Archives of Dermatology

No comments:

Post a Comment